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. 2016 Jul 8;11(7):e0158799. doi: 10.1371/journal.pone.0158799

Fig 2. Lung injury main features according to the experimental condition.

Fig 2

Six representative light microphotographs of rabbit lungs in various conditions fixed at the same transpulmonary pressure (hematoxylin and eosin x400): (A) spontaneously breathing (SB) healthy rabbit (SB); (B) healthy rabbits submitted to a 32-hours mechanical ventilation (MV); (C) SB rabbits 8 hours after tracheal instillation of 109 CFU of Staphylococcus aureus; (D) MV rabbits 8 hours after tracheal instillation of 109 CFU of bacteria; (E) SB rabbits 24 hours after tracheal instillation of 109 CFU of S. aureus; (F) MV rabbits 24 hours after tracheal instillation of 109 CFU of S. aureus. We observed interalveolar septa thickened by an interstitial cell infiltrate and several alveoli collapsed mainly in the MV groups (B, D, F). CFU: colony forming unit.