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Hypothetical relationships between UBR-5 and SEL-10 activity in the embryo. (A) UBR-5 and SEL-10 may each primarily limit signaling activity via one Notch-type receptor and only play a minor role in limiting signaling via the other receptor. (B) UBR-5 and SEL-10 may limit signaling via both GLP-1 and LIN-12, with UBR-5 having a primary role in the early embryo and both factors acting in the late embryo.
