. 2016 May 19;6(7):2225–2235. doi: 10.1534/g3.116.030080

Table 1. Mutations in numerous cilia genes leads to resistance in neomycin-induced hair cell death.

	Wild-Type Sibling			Mutant
Gene	Control	200 μM Neomycin	% HCs Remaining	Control	200 μM Neomycin	% HCs Remaining
Ciliary axoneme and intraflagellar transport
dync2h1 (w46)	12.13 ± 1.15	1.05 ± 0.33	8.65	8.65 ± 1.27	5.63 ± 1.26	65.13
dync2h1 (w46)	12.13 ± 1.15	1.05 ± 0.33	8.65	P < 0.0001	P < 0.0001	65.13
wdr35 (w150)	11.37 ± 0.92	1.84 ± 0.63	16.18	10.10 ± 0.89	6.17 ± 1.41	61.89
wdr35 (w150)	11.37 ± 0.92	1.84 ± 0.63	16.18	P = 0.0002	P < 0.0001	61.89
ift88 (tz288)	12.38 ± 1.78	1.17 ± 0.71	9.42	9.27 ± 0.65	4.43 ± 1.70	47.74
ift88 (tz288)	12.38 ± 1.78	1.17 ± 0.71	9.42	P < 0.0001	P < 0.0001	47.74
traf3ip1 (tp49d)	11.6 ± 1.43	1.08 ± 0.55	9.34	6.73 ± 0.79	4.78 ± 0.69	71.04
traf3ip1 (tp49d)	11.6 ± 1.43	1.08 ± 0.55	9.34	P < 0.0001	P < 0.0001	71.04
arl13b (hi459Tg)	11.78 ± 1.54	1.65 ± 0.85	14.00	11.92 ± 1.01	1.30 ± 0.37	10.88
arl13b (hi459Tg)	11.78 ± 1.54	1.65 ± 0.85	14.00	P = 0.9556	P = 0.7145	10.88
Transition zone
cc2d2a (w38)	11.10 ± 1.72	1.53 ± 0.69	13.78	12.33 ± 1.93	3.68 ± 0.47	29.85
cc2d2a (w38)	11.10 ± 1.72	1.53 ± 0.69	13.78	P = 0.0975	P = 0.0023	29.85
cc2d2a (w123)	12.78 ± 2.5	1.17 ± 0.38	9.13	12.73 ± 2.24	3.05 ± 0.48	23.95
cc2d2a (w123)	12.78 ± 2.5	1.17 ± 0.38	9.13	P = 0.9973	P = 0.0373	23.95
mks1 (w152)	12.34 ± 0.86	1.26 ± 0.46	10.21	12.17 ± 0.83	2.88 ± 0.65	23.66
mks1 (w152)	12.34 ± 0.86	1.26 ± 0.46	10.21	P = 0.6768	P < 0.0001	23.66
cep290 (fh378)	12.30 ± 1.02	1.44 ± 0.34	11.70	12.19 ± 1.04	2.24 ± 0.88	18.34
cep290 (fh378)	12.30 ± 1.02	1.44 ± 0.34	11.70	P = 0.7217	P = 0.0244	18.34

Numbers are average number of hair cells/neuromast ± SD. Significance was calculated using an ANOVA (analysis of variance) and Šídák multiple comparisons test. n = 10 for dync2h1, ift88, traf3ip, arl13b, cc2d2a^w38, and cc2d2a^w123, n = 16 for cep290, n = 31–37 for wild-type siblings, and n = 8–14 for mutants of wdr35 and mks1. HCs, hair cells.