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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Structure. 2016 Jun 2;24(7):1068–1080. doi: 10.1016/j.str.2016.04.015

Figure 8. Bilateral model for Rev-RRE RNP formation.

Figure 8

We propose an updated model for RNP formation that uses the C-C interface to help explain previously reported data.

(A) Rev nucleates at the Stem loop IIB site, whereb

(B) two additional Rev subunits are recruited across the RRE at Stem loop IA. The interaction of these two dimers via their C-C interface may be the specificity checkpoint characterized by Bai et al., 2014.

(C) Finally, additional Rev subunits may oligomerize onto the RRE along Stem loop I. The proximity of Rev subunits in this bilateral manner may induce organization and dimerization of the CTD and subsequently, engagement of the CRM1 pathway. A-A, B-B, and C-C interfaces are colored blue, orange, and green, respectively, and ARMs are colored in navy blue.