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. Author manuscript; available in PMC: 2017 Jul 8.
Published in final edited form as: Circ Res. 2016 May 25;119(2):249–260. doi: 10.1161/CIRCRESAHA.115.308238

Figure 5. Dusp8 KO mice are protected from heart failure following MI injury.

Figure 5

A, Area-at-risk (AAR) normalized to the perfused-area of the left ventricle (LV) in Dusp8 WT and KO mice subjected to 60 minutes of ischemia followed by 24 hours of reperfusion. Number of mice analyzed is shown in the bars. B, Assessment of infarct-area normalized to area-at-risk (IA/AAR) in the hearts of Dusp8 WT and KO mice after I/R injury. Number of mice analyzed is shown in the bars. C, Echocardiographic assessment of FS in Dusp8 WT and KO mice subjected to a sham or a MI procedure for the indicated times. *p<0.05 vs KO MI. D, Echocardiographic parameters in Dusp8 WT and KO mice 3 weeks after MI surgery. LVIDd and LVIDs, left ventricular end-diastolic and end-systolic chamber diameters; IVSd and IVSs, intraventricular end-diastolic and end-systolic septal thickness. LVWd and LVWs, left ventricular end-diastolic and end-systolic posterior wall thickness. *p<0.05 vs WT after MI. Number of mice analyzed is shown in the bars. E, Masson trichrome-stained histological heart sections from Dusp8 WT and KO mice 3 weeks after MI or sham.