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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Structure. 2016 Jun 16;24(7):1044–1056. doi: 10.1016/j.str.2016.04.020

Figure 1. Sequence alignment of selected NATs and overall structure of the binary hNaa60/CoA-Ac-MKAV7 complex.

Figure 1

A) Sequence alignment of hNaa60 (1–184) and NAT homologues hNaa50, hNaa40 (50–237), SsNAT (50–216) and SpNaa10 for which crystal structures already have been determined, and the human homologues hNaa20 and hNaa30 (200–362). Sequence identity is shown with white letters in red boxes and sequence similarity with red letters in blue frames. The secondary structure elements of hNaa60 are shown on top of the alignment. The β3–β4 loop is marked in pink and the β6–β7 loop in light blue. B) IC50 values of the two bisubstrate analogues CoA-Ac-MAPL7 and CoA-Ac-MKAV7 in addition to the control compound desulfoCoA. C) Overall structure of the binary hNaa60/CoA-Ac-MKAV7 complex. The β3–β4 loop is shown in pink (on the back side of the structure), the β6–β7 loop in light blue, and the CoA-Ac-MKAV7 inhibitor in green sticks. See also Figure S1–S3.