TABLE 4.
Comparison of CDR2 amino acid residues for VH1-69 encoded antibody heavy chains
| Antibody | Heavy chain amino acid | Reference | ||||||
|---|---|---|---|---|---|---|---|---|
| 56 | 57 | 58 | 59 | 60 | 61 | 62 | ||
| 1-69*01 germline gene | I | I | P | I | -- | -- | F | IMGT35 |
| 1-69*09 & *10 germline genes | . | . | . | . | -- | -- | L | IMGT35 |
|
| ||||||||
| I-9, I-10, I-27 | . | . | . | . | -- | -- | . | Luken26; Pos27 |
|
| ||||||||
| B-2, B-6, B-5, 3j | . | . | . | . | -- | -- | . | Schaller28 |
|
| ||||||||
| II-1 | . | . | . | . | -- | -- | Y | Pos27 |
|
| ||||||||
| 3b | . | . | . | . | -- | -- | Y | Schaller28 |
|
| ||||||||
| 1-416 | V | . | . | V | -- | -- | L | current study |
| 1-420, 1-401, 1-458, 1-450, 1-418, 1-413, 2-103, 2-106, 2-302, 4-303, 3-302, 3-305, 3-405, 3-301 | . | . | . | . | -- | -- | L | |
| 1-428, 1-304, 1-408, 1-405, 1-423 | . | . | . | V | -- | -- | L | |
| 1-431 | F | V | . | . | -- | -- | L | |
| 1-417, 1-303, 1-406 | F | . | . | . | -- | -- | L | |
| 1-438 | V | . | . | . | -- | -- | L | |
| 1-434, 1-432, 2-204, 2-305, 2-406, 2-203, 2-206, 2-408 | . | V | . | . | -- | -- | L | |
| 2-102 | V | V | . | . | -- | -- | L | |
| 2-207, 2-301, 2-304 | . | T | . | . | -- | -- | L | |
| 4-307 | . | . | . | M | -- | -- | . | |
|
| ||||||||
| PX4-3 | . | . | . | T | -- | -- | L | Payne33 |
Antibodies are grouped by identical CDR2 amino acid residues in positions 56-62. Replacement mutations are indicated with letters, identities with “.”, and gaps with “--“. CDR2 numbering designations per Brochet et al.35