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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Med Genet. 2016 Feb 26;53(5):298–309. doi: 10.1136/jmedgenet-2015-103529

Table 3.

Association between protein truncating variants in BRIP1 and breast cancer risk by subtype

ER-positive
ER-negative
Triple negative
Study Carrier/total (%) OR (95% CI) p Value Carrier/total (%) OR (95% CI) p Value Carrier/total (%) OR (95% CI) p Value
BCAC 4/27,680 (0.01%) 0.38 (0.13 to 1.15) 0.09 8/7707 (0.10%) 2.25 (0.93 to 5.46) 0.07 4/2983 (0.13%) 3.62 (0.99 to 13.2) 0.05
SEARCH 14/7391 (0.19%) 0.76 (0.36 to 1.63) 0.56 2/1521 (0.13%) 0.53 (0.06 to 2.34) 0.54 1/551 (0.18%) 0.73 (0.02 to 4.89) 1.0
Combined 0.61 (0.33 to 1.13) 0.12 1.71 (0.77 to 3.80) 0.19 2.71 (0.84 to 8.74) 0.10

BCAC, Breast Cancer Association Consortium; ER, oestrogen receptor.