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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Med Genet. 2016 Feb 26;53(5):298–309. doi: 10.1136/jmedgenet-2015-103529

Table 4.

Association between missense variants in BRIP1 with Combined Annotation-Dependent Depletion score >20 and breast cancer risk

Study Case carriers/total (%) Control carriers/total (%) OR (95% CI) p Value
BCAC 429/47,666 (0.90%) 370/43,176 (0.86%) 1.06 (0.92 to 1.22) 0.43
SEARCH 276/13,213 (2.1%) 107/5242 (2.0%) 1.06 (0.85 to 1.32) 0.66
BCFR 0/1313 (0%) 1/1123 (0.09%) –
PeterMac 40/1853 (2.2%) 28/2001 (1.4%) 1.68 (1.02 to 2.82) 0.03
Combined 1.08 (0.95 to 1.24) 0.25

BCAC, Breast Cancer Association Consortium; BCFR, Breast Cancer Family Registry.