Association results for all SNPs with six phenotypes.
(a–f) The phenotypes analyzed include risk
of ER+ breast cancer in BCAC (a), risk of
ER− breast cancer in BCAC (b), risk of
triple-negative breast cancer, derived from the CIMBA meta-analysis of
BRCA1 mutation carriers with ER− tumors
(c), risk of HER2+ breast cancer in BCAC
(d), mammographic dense area in MODE (e) and tumor
grade after adjustment for ER status in BCAC (f).
P values for each SNP (from unconditional logistic
regression) are shown plotted as the negative log-transformed P
value against relative position across the locus. A schematic of the gene
structures is shown above a and d. The physical
positions of signals 1–5 are shown as colored, numbered stripes. Dotted
horizontal lines indicate the genome-wide significance level.