TABLE 1.

Characteristics of NF1 Adults With Progressive Extra-Optic Pilocytic Astrocytomas

Pt	Age at NF1 Dx	Clinical criteria at NF1 Dx	Other NF1 stigmata	Decade of age at tumor Dx	Tumor histology	Tumor location	Indication for evaluation	Timeline of symptomatic progression (months)	Treatment	Survival from symptom onset (days)
1	Infancy	CALM, dermal NF	DD	40’s	PA	Medulla	Clinical progression	4	STR, RT	330
2	Childhood	CALM, freckling, LN	DD	20’s	PAa	Brainstem	Radiographic progression	5	STR, Carbo/Vinc, RT+Bev	611
3	5 yrs	CALM, dermal NF	OPG	30’s	PA	Cerebellum	Clinical progression	7	STR, Carbo/Vinc, everolimus+Bev	844

Dx, diagnosis; NF1, neurofibromatosis type 1; CALM, café au lait macules; NF, neurofbroma; LN, Lisch nodule; DD, developmental delay; OPG, optic pathway glioma; PA, pilocytic astrocytoma; STR, subtotal resection; Carbo, carboplatinum; Vinc, vincristine; RT, radiotherapy; Bev, bevacizumab.

^aDenotes that histopathologic diagnosis was pilocytic astrocytoma with anaplastic features as detailed in Table II.