TABLE II.
Histopathologic Characteristics of Progressive Extra-Optic Pilocytic Astrocytomas in NF1 Adults
| Pt | Histologic diagnosis |
Infiltration (Y/N) |
Rosenthal fibers (Y/N) |
EGBs (Y/N) |
Myxoid background (Y/N) |
Mitotic activity (Low/Mod) |
Cytologic atypia (Mild/Mod) |
Cell density (Mild/Mod) |
Necrosis (Y/N) |
Microvascular proliferation (Y/N) |
OD-like areas (Y/N) |
MIB-1a |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | PA | Y | Y | Y | Y | Low | Low | Modb | N | N | N | 5 |
| 2 | PAc | Y | Y | Y | N | Mod | Mod | Mod | Y | N | Y | 20 |
| 3 | PA | Y | Y | N | N | Low | Mild | Mild | N | N | N | 2 |
EGBs, eosinophilic granular bodies; OD-like areas, oligodendroglial-like areas; Y, yes; N, no; mod, moderate; min, minimum.
Description of histologic characteristics of the three adult NF1 patients.
a
Mib-1 was based on minimum cell count of 400.
b
Focally high areas of cell density were noted in this specimen.
c
Anaplasia was noted histologically in this specimen.