Table 2.
Growth inhibitory effects of plant extracts/fractions against tumor cell lines
| No. | Plant species | Parts of the planta (Extractionsb) | Cellc growth inhibition percentage (GI %)d | |
|---|---|---|---|---|
| HepG2 | HL60 | |||
| 01 | Byrsonima sericea DC. | F (e) | 25.03 ± 5.24 | 25.27 ± 8.79 |
| 02 | S (e) | 8.02 ± 6.85 | 27.32 ± 0.06 | |
| 03 | L (e) | 21.84 ± 2.64 | 64.71 ± 5.28 | |
| 04 | L (m/e) | 91.16 ± 0.64 | 102.7 ± 1.12 | |
| 05 | L (ea/e) | 92.14 ± 0.64 | 103.3 ± 7.26 | |
| 06 | L (c/e) | 39.96 ± 9.49 | 70.12 ± 11.24 | |
| 07 | L (h/e) | 91.62 ± 0.39 | 109.0 ± 2.52 | |
| 08 | Cupania impressinervia Acev. Rodr. var. (revoluta) Radlk | L (e) | 23.10 ± 5.59 | 55.19 ± 5.50 |
| 09 | Duranta repens Linn. | FL (m/e) | 14.09 ± 7.14 | 33.3 ± 0.92 |
| 10 | FL (ea/e) | 20.57 ± 7.67 | 28.36 ± 0.46 | |
| 11 | FL (c/e) | 79.94 ± 2.97 | 98.67 ± 6.35 | |
| 12 | Helicostylis tomentosa (Poepp. & Endl) Rusby | S (e) | 14.55 ± 3.30 | 53.67 ± 0,58 |
| 13 | L (e) | 7.96 ± 3.56 | 38.39 ± 7.33 | |
| 14 | Himatanthus bracteatus (A.DC.) Woodson | S (e) | 20.55 ± 1.61 | 29.38 ± 1.63 |
| 15 | L (e) | −9.90 ± 6.56 | −16.91 ± 4.61 | |
| 16 | L (h) | 14.78 ± 5.22 | 70.63 ± 2.62 | |
| 17 | L (m/e) | −0.77 ± 2.61 | 28.55 ± 3.25 | |
| 18 | L (ea/e) | 5.70 ± 2.61 | 56.16 ± 9.49 | |
| 19 | L (c/e) | 92.30 ± 1.50 | 93.63 ± 0.30 | |
| 20 | Ipomoea purga (Wender.) Hayne | S (e) | 98.39 ± 1.81 | 95.58 ± 1.33 |
| 21 | L (e) | 93.86 ± 2.70 | 106.4 ± 3.62 | |
| 22 | Ixora coccinea Linn. | F (e) | −2.97 ± 9.22 | 1.27 ± 3.86 |
| 23 | FL (h) | 21.47 ± 5.44 | −25.64 ± 9.33 | |
| 24 | L (m/e) | 9.25 ± 4.73 | 1.38 ± 1.35 | |
| 25 | L (ea/e) | 7.49 ± 5.16 | 32.25 ± 9.39 | |
| 26 | L (h/e) | 22.55 ± 3.23 | 58.78 ± 1.34 | |
| 27 | F (ea/e) | −5.53 ± 7.07 | 18.83 ± 5.74 | |
| 28 | F (c/e) | 94.93 ± 0.74 | 92.97 ± 2.39 | |
| 29 | Mabea piriri Aubl. | S (e) | 81.41 ± 8.27 | 92.35 ± 7.66 |
| 30 | L (e) | 12.48 ± 5.12 | 69.56 ± 0.17 | |
| 31 | Miconia minutiflora | S (e) | 25.64 ± 6.34 | 38.17 ± 1.16 |
| 32 | L (e) | 38.62 ± 2.72 | 66.54 ± 0.85 | |
| 33 | Momordica charantia L. | L (e) | −17.51 ± 2.97 | 9.30 ± 5.64 |
| 34 | Ocotea glomerata (Nees) Mez | S (e) | 49.49 ± 9.87 | 32.70 ± 9.32 |
| 35 | L (c/e) | 25.48 ± 7.87 | 52.0 ± 3.12 | |
| 36 | Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees) | S (e) | −7.43 ± 5.88 | 2.49 ± 0.33 |
| 37 | L (e) | 93.88 ± 2.12 | 94.70 ± 1.06 | |
| 38 | Pavonia fruticosa (Mill.) Fawc. & Rendle | S (e) | 44.81 ± 1.66 | 41.65 ± 6.51 |
| 39 | L (e) | 33.34 ± 4.48 | 55.82 ± 4.66 | |
| 40 | Psychotria capitata Ruiz & Pav. | S (e) | 15.82 ± 3.12 | 64.16 ± 0.32 |
| 41 | L (e) | 28.13 ± 8.45 | 22.00 ± 5.92 | |
| 42 | L (m/e) | 19.16 ± 8.90 | 51.72 ± 4.86 | |
| 43 | L (ea/e) | 95.14 ± 1.83 | 86.55 ± 4.20 | |
| 44 | L (c/e) | 96.92 ± 1.68 | 92.87 ± 0.06 | |
| 45 | L (h/e) | 12.28 ± 4.71 | −26.37 ± 1.89 | |
| 46 | L (h:ea/e) | 61.84 ± 9.74 | 48.62 ± 1.18 | |
| 47 | Schefflera morototoni (Aubl.) Maguire, Steyerm. & Frodin | S (e) | 42.73 ± 1.59 | −23.89 ± 3.53 |
| 48 | L (e) | 9.05 ± 7.07 | 63.74 ± 8.13 | |
| 49 | Solanum paludosum Moric. | S (e) | 17.69 ± 5.22 | 63.81 ± 2.08 |
| 50 | Xylopia frutescens Aubl. | S (e) | 19.36 ± 3.74 | 72.39 ± 2.90 |
| 51 | L (m/e) | 29.88 ± 2.90 | 18.19 ± 6.52 | |
| 52 | L (ea/e) | 19.46 ± 7.46 | 51.24 ± 5.86 | |
| 53 | L (c/e) | 71.00 ± 3.06 | 62.71 ± 4.30 | |
| 54 | L (h/e) | 23.49 ± 3.57 | 69.41 ± 0.88 | |
| 55 | Zanthoxylum rhoifolium Lam. | L (e) | 15.53 ± 5.03 | 14.00 ± 4.00 |
| Doxorubicine | 85.20 ± 0.78 | 86.34 ± 2.27 | ||
aParts of the plant: L leaves, S stem, F Fruits, FL flowers
bExtractions: h hexane, m methanol, e ethanol, m/e methanol/water partition from the ethanolic extract, ea/e ethyl acetate partition from the ethanolic extract, h/e hexane partition from the ethanolic extract, c/e chloroform partition from the ethanolic extract, h:ea/e, hexane:ethyl acetate (1:1) partition from the ethanolic extract
cCell lines: HepG2 (human hepatocellular carcinoma) and HL60 (human promyelocytic leukemia)
dGI % values are presented as the mean ± S.E.M. of two independents experiment performed in triplicate measured by the alamar blue assay after 72 h incubation. All extracts were tested at a concentration of 50 μg/mL. The negative control received the vehicle used to dilute the tested samples (0.5 % DMSO)
eDoxorubicin was used as the positive control