Table 3.
Microarray analysis of genes related to the IL-10 pathway whose expression in THP-1 monocytes was affected by incubation with B. burgdorferi and tick saliva at 2 and 12 h post-incubation
| Gene identifier | B. burgdorferi | B. burgdorferi + saliva | ||
|---|---|---|---|---|
| 2 h | 12 h fold-change | 2 h | 12 h | |
| BCL3 | 2.2 | na | 1.3 | na |
| BLVRE | naa | -2.6 | na | na |
| CCR1 | na | na | -1.1 | na |
| CD14 | -1.2 | na | na | na |
| ELK1 | na | -1.0 | na | na |
| FCGR2A | na | -1.9 | na | na |
| FCGR2B | na | -1.3 | na | na |
| FCGR2C | na | -1.7 | na | na |
| FOS | na | -1.6 | na | na |
| HMOX1 | na | 2.0 | na | na |
| IKBKG | na | 4.0 | na | na |
| IL10RA | -1.8 | na | na | na |
| IL10RB | na | -1.1 | na | na |
| IL1B | 3.3 | 2.7 | na | na |
| IL1F5 | -2.3 | na | na | na |
| IL1F9 | na | 5.1 | na | na |
| IL1F10 | 6.7 | na | na | na |
| IL1R1 | na | na | na | -1.3 |
| JUN | na | 4.9 | na | na |
| MAP2K3 | -1.3 | -2.1 | na | na |
| MAP3K7 | na | 5.0 | na | na |
| MAP3KK7I | -2.0 | na | na | na |
| MAP4K4 | -3.2 | 4.9 | 1.3 | na |
| MAPK8 | -1.5 | na | na | na |
| MAPK12 | -1.1 | -2.9 | na | na |
| MAPK13 | -1.1 | na | na | na |
| MAPK14 | -4.2 | 3.6 | na | 1.3 |
| SOCS3 | na | 5.8 | 1.4 | na |
| STAT3 | na | -1.0 | na | na |
| SP1 | -1.6 | na | na | na |
| TNF-α | na | 4.5 | na | na |
| TYK2 | na | -1.9 | na | na |
ana, no data were generated for this gene identifier at this particular time point under those experimental conditions