Table 1.
Inferred human gut Firmicutes CsoR meta-regulon
| eggNOG / COG | eggNOG 4.0 annotation | Domains | Mapped operons | Operons for analysis | P(R|D) | Operon with COG1937 | Operon with COG2217 | Dual sites |
|---|---|---|---|---|---|---|---|---|
| COG1937 | Transcriptional repressor | IPR003735 | 530 | 332 | 1 | 332 | 94 | 93/221 |
| COG2217 | p-type ATPase | IPR006121, IPR023214, IPR008250 | 1580 | 422 | 1 | 84 | 422 | 94/204 |
| NOG218972 | Heavy-metal-associated domain | IPR006121 | 16 | 7 | 1 | 1 | 2 | 3/7 |
| NOG72602 | Predicted membrane protein | IPR018758 | 16 | 5 | 1 | 0 | 0 | 1/4 |
| NOG109008 | N/A | IPR018242 | 18 | 5 | 1 | 0 | 0 | 0/5 |
| COG2836 | Membrane protein | IPR006121, IPR003834, IPR018758 | 36 | 8 | 1 | 0 | 1 | 1/3 |
| NOG81268 | Heavy-metal-associated domain | IPR006121 | 34 | 6 | 1 | 0 | 1 | 1/5 |
Operons for analysis denotes the total number of operons mapping to each eggNOG/COG after sensitivity adjustment. P(R|D) designates the posterior probability of regulation for the eggNOG/COG. The Operon with COG1937 and Operon with COG2217 columns indicate the number of genes mapping to an eggNOG/COG that were assigned to an operon containing also COG1937 or COG2217, respectively. Dual sites denotes the number of sequences mapping to an eggNOG/COG harboring two high-confidence sites, out of the total number of sequences mapping to that eggNOG/COG with high-confidence sites