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. 2016 Jul 8;16:99. doi: 10.1186/s12886-016-0275-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a, b The fundus examination and the fundus autofluorescence of the left eye was normal 1 year after the first clinical visit (14 months after the injury). White square and white line indicate AO-SLO image (i) and SD-OCT (e), respectively. c Humphrey visual field 10–2 showed a para-central blind spot in the left eye at 14 months after the injury. d The fundus photo was also normal at 22 months after the injury. e, f, g, h SD-OCT (e, g; 14 months, F, H; 22 months) showed a continuous but slightly depressed ellipsoid zone (white arrow in g). g and h show magnified images of the white dotted square in e and f, respectively. The blue arrow indicates the area of intact interdigitation zone, whereas the pink arrow indicates the area of disrupted interdigitation zone. i The AO-SLO montage (1 mm X 2 mm) of the fovea in the left eye showed an area with reduced cone reflectivity corresponding to the area of the scotoma (yellow arrows). Yellow and white dotted squares indicate AO-SLO image at the 0.25 mm nasal and 0.34 mm superior areas from the fovea, respectively, 14 months after the first visit. The asterisk indicates the central fovea. j, k AO-SLO images at the yellow dotted square (j) showed patchy reduced cone reflectivity. AO-SLO at the white dotted square (k) showed normal cone spacing. m, n Color maps of the cone mosaic in the white and yellow dotted squares (Red > 250 μm², Orange = 200-250 μm², Yellow = 150-200 μm², Green = 150-200 μm², blue = 100-150 μm²). The analysis revealed that the cone mosaic of the yellow dotted square (cone density, 16503/mm²; ratio of hexagonal Voronoi domain, 36.3 %; average NND/expected NND, 0.606) was disordered compared with the white dotted square (cone density, 24821/mm²; ratio of hexagonal Voronoi domain, 44.1 %; average NND/expected NND, 0.739). l AO-SLO image at the 0.25 mm nasal area in the 29-year healthy man. o Color map of cone mosaic of the imaged area in the 29-year-old man (cone density, 38750/mm²; ratio of hexagonal Voronoi domain, 43.1 %; average NND/expected NND, 0.718)