Table 1.
Characteristics according to randomization group during the cooling and ECLS rewarming phase
| Cooling phase | ECLS rewarming phase | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 32 | 30 | 25 | 20 | 20 | 25 | 30 | 35 | ||
| LF group | HR, beats/min | 100 ± 5 | 84 ± 9 | 70 ± 5 | 55 ± 4 | 29 ± 9 | 88 ± 15 | 124 ± 6 | ||
| AP, mmHg | 72 ± 7 | 70 ± 4 | 44 ± 4 | 29 ± 2 | 19 ± 4 | 27 ± 3* | 35 ± 3* | 70 ± 9 | 63 ± 8 | |
| PAP, mmHg | 20 ± 2 | 28 ± 7 | 24 ± 3 | 19 ± 3 | 13 ± 2 | 8 ± 1 | 11 ± 2 | 19 ± 3 | 33 ± 3 | |
| PVR, dyn · s · cm−5 | 234 ± 50 | 487 ± 132 | 515 ± 139 | 800 ± 419 | 951 ± 229 | |||||
| EtCO2, mmHg | 42 ± 4 | 27 ± 1 | 29 ± 1.3 | 24 ± 2 | 23 ± 1 | 11 ± 2 | 5 ± 1 | 16 ± 3 | 33 ± 3 | |
| CO, L/min | 4.4 ± .4 | 3.3 ± .4 | 2.8 ± .3 | 2.3 ± .5 | 1.4 ± .3& | 2.7 ± .5 | ||||
| pH | 7.40 ± .02 | 7.43 ± .02 | 7.39 ± .03 | 7.35 ± .04 | 7.18 ± .02 | 7.28 ± .04 | 7.36 ± .06 | 7.35 ± .05 | 7.38 ± .04 | |
| PO2/FiO2, mmHg | 449 ± 40 | 598 ± 69 | 547 ± 68 | 549 ± 74 | 523 ± 191 | 386 ± 78 | 934 ± 145 | 480 ± 118 | 398 ± 123 | |
| PCO2, mmHg | 51 ± 3 | 40 ± 2 | 46 ± 3 | 49 ± 5 | 56 ± 10 | 54 ± 6 | 47 ± 6 | 43 ± 5 | 37 ± 3 | |
| Serum lactate, mmol/L | 2.09 ± .21 | 7.66 ± 1.55 | 5.44 ± .54* | |||||||
| Serum potassium, mmol/L | 3.87 ± .15 | 3.97 ± .13 | 3.77 ± .17 | |||||||
| NF group | HR, beats/min | 107 ± 9 | 80 ± 6 | 68 ± 6 | 51 ± 5 | 25 ± 10 | 91 ± 9 | 138 ± 9 | ||
| AP, mmHg | 68 ± 3 | 66 ± 5 | 46 ± 5 | 28 ± 3 | 20 ± 1 | 41 ± 3* | 48 ± 3* | 64 ± 6 | 74 ± 7 | |
| PAP, mmHg | 21 ± 3 | 32 ± 15 | 20 ± 2 | 16 ± 2 | 15 ± 6 | 11 ± 1 | 12 ± 1 | 18 ± 3 | 29 ± 3 | |
| PVR, dyn · s · cm−5 | 287 ± 55 | 461 ± 54 | 453 ± 121 | 480 ± 208 | 499 ± 93 | |||||
| EtCO2, mmHg | 42 ± 4 | 25 ± 4 | 26 ± 2 | 22 ± 2 | 19 ± 3 | 11 ± 2 | 7 ± 2 | 12 ± 3 | 30 ± 4 | |
| CO, L/min | 4.4 ± .4 | 3.0 ± .4 | 2.5 ± .2 | 1.9 ± .1 | 1.7 ± .6& | 3.9 ± .5 | ||||
| pH | 7.40 ± .02 | 7.45 ± .14 | 7.41 ± .04 | 7.38 ± .03 | 7.34 ± .01 | 7.33 ± .03 | 7.27 ± .03 | 7.37 ± .03 | 7.39 ± .03 | |
| PO2/FiO2, mmHg | 433 ± 52 | 514 ± 164 | 574 ± 51 | 684 ± 85 | 369 ± 45 | 344 ± 35 | 783 ± 158 | 755 ± 103 | 382 ± 59 | |
| PCO2, mmHg | 49 ± 3 | 43 ± 16 | 43 ± 4 | 46 ± 3 | 48 ± 3 | 52 ± 5 | 51 ± 3 | 38 ± 3 | 33 ± 3 | |
| Serum lactate, mmol/L | 2.27 ± .20 | 5.30 ± .86 | 3.91 ± .50* | |||||||
| Serum potassium, mmol/L | 3.96 ± .08 | 3.99 ± .16 | 3.76 ± .17 | |||||||
Groups: LF/low blood flow rate of 1.5 L/min; NF/normal blood flow rate of 3 L/min. PaO 2 /FiO 2 arterial oxygen pressure/inspired oxygen fraction, ABP arterial blood pressure, PAP pulmonary arterial pressure, PVR pulmonary vascular resistance. Values are presented as mean ± SEM. & measured only on 6 pigs in each group that achieved ROSC at this time point. * p < 0.05 compared with the other group