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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Cancer Causes Control. 2016 Jun 13;27(7):929–940. doi: 10.1007/s10552-016-0773-y

Table 3.

Association of childhood ALL with intake of one-carbon metabolism nutrients before pregnancy from food and supplements and food only, by maternal race/ethnicity

All mothersa
645 cases,
854 controls
Hispanic mothersa
185 cases,
226 controls
White mothersa
253 cases,
357 controls
Asian mothersa
68 cases,
79 controls
Nutrients from food and
supplements
(Unit-change for OR)
Odds Ratio
(95% CI)
Odds Ratio
(95% CI)
Odds Ratio
(95% CI)
Odds Ratio
(95% CI)
Principal component
(one-unit change)*b
0.91 (0.84–0.99) 0.79 (0.64–0.97) 0.92 (0.81–1.03) 1.08 (0.81–1.44)
Folate (100 DFE/day)* 0.97 (0.94–1.01) 0.92 (0.84–1.01) 0.98 (0.93–1.03) 1.02 (0.89–1.17)
Vitamin B12 (1 µg/day)* 0.96 (0.93–1.00) 0.94 (0.87–1.02) 0.95 (0.90–1.01) 1.01 (0.89–1.14)
Vitamin B6 (1 mg/day)* 0.89 (0.79–1.00) 0.68 (0.50–0.92) 0.90 (0.75–1.08) 1.11 (0.74–1.65)
Riboflavin (1 mg/day)* 0.88 (0.77–1.00) 0.69 (0.49–0.97) 0.87 (0.72–1.07) 1.07 (0.66–1.73)
Nutrients from food only
(Unit-change for OR)
Principal component
(one-unit change)b
0.93 (0.83–1.04) 0.86 (0.68–1.08) 0.89 (0.72–1.09) 0.75 (0.43–1.33)
Folate (100 DFE/day) 0.99 (0.93–1.06) 0.96 (0.85–1.09) 1.00 (0.90–1.12) 0.87 (0.66–1.13)
Vitamin B12 (1 µg/day) 0.97 (0.92–1.02) 0.98 (0.90–1.07) 0.91 (0.82–1.02) 0.85 (0.68–1.07)
Vitamin B6 (1 mg/day) 0.91 (0.74–1.12) 0.69 (0.45–1.08) 0.88 (0.59–1.29) 0.75 (0.34–1.63)
Riboflavin (1 mg/day) 0.91 (0.74–1.12) 0.78 (0.51–1.20) 0.85 (0.60–1.19) 0.59 (0.24–1.43)
Methionine(1 g/day)*c 0.90 (0.73–1.10) 0.75 (0.50–1.15) 0.78 (0.54–1.14) 1.39 (0.70–2.75)

Conditional logistic regression models adjusted for father’s education, mother’s education, household income, maternal age at child’s birth, and energy intake. Models for all mothers also adjusted for mother’s ethnicity. Models for nutrient intake from food only also adjusted for intake of B vitamin-containing supplements (yes/no).

*

P-value <0.2 for tests of interaction by maternal ethnicity.

a

All mothers includes mothers of all races/ethnicities who responded in English and Spanish. Hispanic mothers include those who responded to the Spanish FFQ and white and Asian mothers include those who responded to the English FFQ.

b

The principal component represents the combined dietary intake of folate, vitamins B12 and B6, riboflavin and methionine from food and supplements and from food only.

c

Methionine was measured from food only.