Table 3.
Association of childhood ALL with intake of one-carbon metabolism nutrients before pregnancy from food and supplements and food only, by maternal race/ethnicity
All mothersa 645 cases, 854 controls |
Hispanic mothersa 185 cases, 226 controls |
White mothersa 253 cases, 357 controls |
Asian mothersa 68 cases, 79 controls |
|
---|---|---|---|---|
Nutrients from food and supplements (Unit-change for OR) |
Odds Ratio (95% CI) |
Odds Ratio (95% CI) |
Odds Ratio (95% CI) |
Odds Ratio (95% CI) |
Principal component (one-unit change)*b |
0.91 (0.84–0.99) | 0.79 (0.64–0.97) | 0.92 (0.81–1.03) | 1.08 (0.81–1.44) |
Folate (100 DFE/day)* | 0.97 (0.94–1.01) | 0.92 (0.84–1.01) | 0.98 (0.93–1.03) | 1.02 (0.89–1.17) |
Vitamin B12 (1 µg/day)* | 0.96 (0.93–1.00) | 0.94 (0.87–1.02) | 0.95 (0.90–1.01) | 1.01 (0.89–1.14) |
Vitamin B6 (1 mg/day)* | 0.89 (0.79–1.00) | 0.68 (0.50–0.92) | 0.90 (0.75–1.08) | 1.11 (0.74–1.65) |
Riboflavin (1 mg/day)* | 0.88 (0.77–1.00) | 0.69 (0.49–0.97) | 0.87 (0.72–1.07) | 1.07 (0.66–1.73) |
Nutrients from food only (Unit-change for OR) |
||||
Principal component (one-unit change)b |
0.93 (0.83–1.04) | 0.86 (0.68–1.08) | 0.89 (0.72–1.09) | 0.75 (0.43–1.33) |
Folate (100 DFE/day) | 0.99 (0.93–1.06) | 0.96 (0.85–1.09) | 1.00 (0.90–1.12) | 0.87 (0.66–1.13) |
Vitamin B12 (1 µg/day) | 0.97 (0.92–1.02) | 0.98 (0.90–1.07) | 0.91 (0.82–1.02) | 0.85 (0.68–1.07) |
Vitamin B6 (1 mg/day) | 0.91 (0.74–1.12) | 0.69 (0.45–1.08) | 0.88 (0.59–1.29) | 0.75 (0.34–1.63) |
Riboflavin (1 mg/day) | 0.91 (0.74–1.12) | 0.78 (0.51–1.20) | 0.85 (0.60–1.19) | 0.59 (0.24–1.43) |
Methionine(1 g/day)*c | 0.90 (0.73–1.10) | 0.75 (0.50–1.15) | 0.78 (0.54–1.14) | 1.39 (0.70–2.75) |
Conditional logistic regression models adjusted for father’s education, mother’s education, household income, maternal age at child’s birth, and energy intake. Models for all mothers also adjusted for mother’s ethnicity. Models for nutrient intake from food only also adjusted for intake of B vitamin-containing supplements (yes/no).
P-value <0.2 for tests of interaction by maternal ethnicity.
All mothers includes mothers of all races/ethnicities who responded in English and Spanish. Hispanic mothers include those who responded to the Spanish FFQ and white and Asian mothers include those who responded to the English FFQ.
The principal component represents the combined dietary intake of folate, vitamins B12 and B6, riboflavin and methionine from food and supplements and from food only.
Methionine was measured from food only.