. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Cancer Causes Control. 2016 Jun 13;27(7):929–940. doi: 10.1007/s10552-016-0773-y

Table 5.

Association of childhood AML with intake of one-carbon metabolism nutrients before pregnancy from food and supplements and food only

	All Mothers 98 cases, 128 controls
Nutrients from food and supplements	Odds Ratio (95% CI)

Principal component^a	0.83 (0.66–1.04)
Folate (100 DFE/day)	0.93 (0.85–1.03)
Vitamin B12 (1 µg/day)	0.92 (0.84–1.02)
Vitamin B6 (1 mg/day)	0.72 (0.51–1.04)
Riboflavin (1 mg/day)	0.85 (0.60–1.20)

Nutrients from food only

Principal component^a	0.68 (0.46–1.02)
Folate (100 DFE/day)	0.90 (0.76–1.07)
Vitamin B12 (1 µg/day)	0.86 (0.73–1.02)
Vitamin B6 (1 mg/day)	0.47 (0.23–0.98)
Riboflavin (1 mg/day)	0.85 (0.49–1.50)
Methionine (1 g/day)^b	0.68 (0.35–1.34)

Conditional logistic regression models adjusted for mother’s ethnicity, father’s education, mother’s education, household income, maternal age at child’s birth, and energy intake. Models for nutrients from food additionally adjusted for B vitamin intake from supplements (yes/no).

The principal component represents the combined dietary intake of folate, vitamins B12 and B6, riboflavin and methionine from food and supplements and from food only.

Methionine was measured from food only.