Table 3.

Parameter estimates from 500 simulated datasets containing N = 10 and N = 30 patients distributed equally to receive one of five dose groups d₁ . . . d₅ over six cycles comparing comparing estimates based on Model 3 (α, β, ρ) that use multiple toxicity responses to estimates based on Models 6 (γ) and 7 (δ) that use a single binary toxicity response.

	Prior Mean (SD)	Estimate(Bias)	MSD1	ESD2	Coverage
N=10 patients
α	1 (2)	0.945 (0.055)	0.682	0.585	99.6
β	0.5 (1)	0.515 (−0.015)	0.464	0.308	100
ρ	0.83 (0.14)	0.820 (−0.020)	0.137	0.040	100
γ	1 (2)	0.916 (0.084)	0.703	0.630	99.8
δ	1 (2)	0.976 (0.024)	0.548	0.536	92.6
N=30 patients
α	1 (2)	0.989 (0.011)	0.466	0.408	96.0
β	0.5 (1)	0.507 (−0.007)	0.343	0.285	98.8
ρ	0.83 (0.14)	0.802 (−0.002)	0.133	0.058	99.8
γ	1 (2)	0.940 (0.060)	0.474	0.428	96.6
δ	1 (2)	0.998 (0.002)	0.333	0.331	94

¹MSD is mean of the SD from 500 estimates

²ESD is empirical SD of the 500 estimates