Table 7.

Trial/Patient summary results for maximizing expected dose over 500 simulated clinical trials. Columns present the 1) mean dose received per patient, 2) mean toxicities over the trials with trial stopping early in parenthesis, 3) average patients having dose ≥ the recommended expected dose, 4) average patients having dose ≥ the target expected dose, 5) average patients having regimen exactly equal to the recommended regimen 6) average patients having regimen exactly equal to the target regimen, 7) average patients having regimen ≤ to the recommended regimen and 8) average patients having regimen ≤ to the target regimen.

	Mean Dose	Mean Toxicities	Patients ≥R.Edose	Patients ≥T.Edose	Patients =R.Dist	Patients =T.Dist	P.R.Dist ≤2	P.T.Dist ≤ 2
Using Pr(A1)&Pr(C) = 0.30
P̊(B) = 0.3, P̊(C) = 0.4
P̊(A1) = 0.05, P̊(A2) = 0.09	15.48	0.31 (48)	20.27	15.02	0.62	0.83	5.66	5.35
P̊(A1) = 0.1, P̊(A2) = 0.08	15.91	0.3 (25)	18.09	18.09	1.64	0.64	11.75	4.89
P̊(A1) = 0.2, P̊(A2) = 0.06	16.21	0.27 (11)	16.73	17.22	3.96	1.83	10.86	8.57
P̊(B) = 0.4, P̊(C) = 0.4
P̊(A1) = 0.05, P̊(A2) = 0.09	15.53	0.31 (48)	20.28	14.96	0.6	0.83	5.4	5.24
P̊(A1) = 0.1, P̊(A2) = 0.08	15.99	0.31 (25)	17.98	17.68	1.59	0.69	11.3	4.67
P̊(A1) = 0.2, P̊(A2) = 0.06	16.33	0.28 (11)	16.82	17.38	4.46	2.16	11.26	9.31
Using Pr(C) = 0.30
P̊(B) = 0.3, P̊(C) = 0.4
P̊(A1) = 0.05, P̊(A2) = 0.09	15.48	0.31 (48)	12.84	12.71	0.45	0.13	8.15	2.09
P̊(A1) = 0.1, P̊(A2) = 0.08	15.91	0.3 (25)	15.46	13.51	1.81	0.68	11.09	4.95
P̊(A1) = 0.2, P̊(A2) = 0.06	16.21	0.27 (11)	16.73	17.22	3.95	1.83	10.81	8.57
P̊(B) = 0.4, P̊(C) = 0.4
P̊(A1) = 0.05, P̊(A2) = 0.09	15.53	0.31 (48)	12.81	12.77	0.43	0.12	7.68	2.22
P̊(A1) = 0.1, P̊(A2) = 0.08	15.99	0.31 (25)	15.29	13.37	1.72	0.65	10.71	5.44
P̊(A1) = 0.2, P̊(A2) = 0.06	16.33	0.28 (11)	16.82	17.38	4.47	2.16	11.24	9.31

T/R.Edose - Target/Recommended expected dose.

T/R.Dist - Distance of patient regimen from Target/Recommended regimen.