Table 1.
Patient Demographics and Antimicrobial Exposure (n=96)
| Patient Characteristics | |
|---|---|
| Median age, IQR | 57 [37, 70] |
| Female Sex (n, %) | 52 (54) |
| Race (n, %) | |
| White | 88 (92) |
| African American | 3 (3) |
| Hispanic | 3 (3) |
| Other/Unknown | 2 (2) |
| Comorbidities (n, %) | |
| Hypertension | 50 (52) |
| Diabetes Mellitus | 32 (33) |
| Coronary or peripheral vascular disease | 27 (28) |
| Chronic kidney disease | 23 (24) |
| Intravenous drug use | 17 (18) |
| Atopy | 12 (13) |
| Hepatitis C infection | 11 (11) |
| HIV infection | 4 (4) |
| Any drug allergy history | 63 (66) |
| Penicillin allergy history | 20 (21) |
| Cephalosporin allergy history | 13 (14) |
|
| |
| Treatment Characteristics | |
|
| |
| Doses of ceftaroline, Median [IQR] | 28 [6–63] |
| Days of ceftaroline, Median [IQR] | 13 [4–30] |
| Concomitant or sequential antibiotic use (n, %) | |
| Daptomycin | 14 (14) |
| Vancomycin | 10 (10) |
| Rifampin | 6 (6) |
| Linezolid | 5 (5) |
| Other * | 43 (44) |
| Infectious Diagnosis (n, %)† | |
| Bacteremia | 34 (35) |
| Orthopedic infections‡ | 27 (28) |
| Skin/soft tissue infections | 27 (28) |
| Pneumonia/empyema | 21 (22) |
| Endocarditis | 14 (15) |
| Vascular graft infection | 8 (8) |
| Intra-abdominal infections | 2 (2) |
| Epidural abscess | 1 (1) |
| Patients Treated Off-Label | 57 (59) |
| Organism (n, %) | |
| MRSA | 52 (54) |
| CoNS | 10 (10) |
| MSSA | 5 (5) |
| Other || | 9 (9) |
| Not identified or recovered | 20 (21) |
Other includes azithromycin, cefazolin, cefepime, ceftazidine, ciprofloxacin, clindamycin, colistin, doxycycline, fluconazole, imipenem, inhaled tobramycin, levofloxacin, meropenem, metronidazole, micafungin, moxifloxacin, nafcillin, piperacillin-tazobactam, and trimethroprim-sulfamethoxazole.
Of the patients with a primary infectious diagnosis of bacteremia some patients also had a secondary diagnosis of endocarditis (n=2), intra-abdominal infection (n=2), pneumonia (n=1); of the with primary orthopedic infections some patients also had a secondary diagnosis of bacteremia (n=8); of the patients with a primary diagnosis of skin and soft tissue infection some patients also had a secondary diagnosis of bacteremia (n=2), pneumonia (n=1), orthopedic (n=2); of the patients with a primary infectious diagnosis of pneumonia some patients also had a secondary diagnosis of bacteremia (n=2); of the patients with a primary diagnosis of endocarditis some patients also had a secondary diagnosis of bacteremia (n=5), pneumonia (n=4), vascular (n=1); of the patients with a primary diagnosis of vascular infection some patients also had a secondary diagnosis of bacteremia (n=2), pneumonia (n=1)
Orthopedic infections include osteomyelitis, prosthetic joint infections, septic arthritis, post-operative spine infections, and infections after fracture/fixation
Includes Pseudomonas aeruginosa (n=2), Enterobacter aerogenes (n=1), Klebsiella pneumoniae (n=1), Candida albicans (n=1), Enterococcus faecalis (n=1), Staphylococcus lugdunensis (n=1), Beta-hemolytic Streptococcus (n=1), Streptococcus pneumoniae (n=1)
Abbreviations: HIV: Human Immunodeficiency Virus, MRSA: Methicillin-resistant Staphylococcus aureus, CoNS: Coagulase-negative Staphylococcus, MRSA: Methicillin-sensitive Staphylococcus aureus