Table 2.
Adverse Drug Reactions to Ceftaroline (n=20)
| Patient number |
Ceftaroline doses prior to ADR |
Clinical Diagnosis Made by* |
Rash† | Transaminitis (Maximum ALT) |
Acute kidney injury (Maximum Cr) |
Leukopenia (MinimumWBC) |
Neutropenia (Minimum ANC) |
Eosinophilia (Maximum AEC) |
Thrombocytopenia (Minimum PLT) |
Fever | C.difficile | Gastrointestinal Upset |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Two or more signs orsymptoms of ADR | 1 | 76 | ID | MUC | ... | ... | ... | 1,260 | 750 | ... | ... | ... | ... |
| 24 | 46 | ID | ... | ... | ... | ... | 270 | ... | ... | X | ... | X | |
| 27 | 40 | ID, H | MP | ... | ... | 1,930 | ... | ... | ... | X | ... | ... | |
| 28 | 129 | ID | ... | ... | ... | 3,500 | ... | ... | 139,000 | ... | ... | ... | |
| 40‡ | 79 | ID | ... | ... | ... | ... | 1,440 | ... | ... | X | ... | ... | |
| 43 | 180 | ID | MP | 369U/L|| | ... | ... | ... | ... | ... | ... | ... | ... | |
| 73 | 24 | AI, ID, D | DES | ... | ... | 2,100 | ... | 910 | ... | ... | ... | ... | |
| 95 | 192 | ID | ... | ... | ... | 3,200 | ... | 760 | ... | ... | ... | ... | |
| Single sign or symptom of ADR | 14‡ | 4 | ID | NC | ... | ... | ... | ... | ... | ... | ... | ... | ... |
| 15 | 94 | ID | ... | ... | ... | ... | ... | ... | ... | ... | X | ... | |
| 16 | 40 | ID | ... | ... | ... | ... | ... | ... | 71,000 | ... | ... | ... | |
| 18 | 18 | ID | MP | ... | ... | ... | ... | ... | ... | ... | ... | ... | |
| 29 | 114 | IM | NC | ... | ... | ... | ... | ... | ... | ... | ... | ... | |
| 31 | 132 | ID, H | ... | ... | ... | ... | 200 | ... | ... | ... | ... | ... | |
| 48 | 24 | ID | MP | ... | ... | ... | ... | ... | ... | ... | ... | ... | |
| 53 | 46 | ID | ... | ... | ... | ... | 1,400 | ... | ... | ... | ... | ... | |
| 62 | 15 | ID, AI | URT | ... | ... | ... | ... | ... | ... | ... | ... | ... | |
| 76‡ | 6 | IM, H | ... | ... | ... | ... | ... | ... | 32,000 | ... | ... | ... | |
| 81 | 48 | ID, N | ... | ... | 2.61 (BL 0.60)§ | ... | ... | ... | ... | ... | ... | ... | |
| 88 | 22 | ID, N | ... | ... | 1.19 (BL 0.66) | ... | ... | ... | ... | ... | ... | ... | |
| Possibly Immune-Mediated HSR | Side effect | ||||||||||||
*
ID: Infectious Disease, H: Hematology, AI: Allergy/Immunology, D: Dermatology, IM: Internal Medicine, N: Nephrology
†
MUC: with mucosal lesions; MP: maculopapular; DES: desquamating; NC: not characterized; URT: urticarial
‡
Patients with prior reported history of beta-lactam allergy.
||
Suspected immune-mediated hepatitis
§
Suspected acute interstitial nephritis
Abbreviations: ADR: adverse drug reaction, ALT: alanine aminotransferase (U/L), Cr: creatinine (mg/dL), WBC: white blood cell count (U/μL), ANC: absolute neutrophil count (U/μL), AEC: absolute eosinophil count (U/L), PLT: platelet count (U/μL), GI: gastrointestinal, BL: baseline, HSR: hypersensitivity reaction.