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Evaluation of the ability of nanochains to target invasive brain tumors in mice. At 8 days after orthotopic inoculation of CNS-1 cells in mice, the animals were injected with various formulations of doxorubicin (DOX) at a dose 0.5 mg/kg DOX. At 24 h after injection, animals were euthanized, brain tumors were excised and DOX content was measured. (reprinted with permission after partial modifications from ref. 12)
