Fig. 2.

The influence of SCH 23390 (a) and sulpiride (b) on the antidepressant-like effect induced by EMD 386088 in the FST in rats. EMD 386088 was administered i.p. 30 min before the test, while SCH 23390 and sulpiride were given 60 min before. The animals were observed for 5 min. The results represent the mean ± SEM of 6–8 rats. The data were statistically evaluated by two-way ANOVA followed by Duncan’s post hoc test: *p < 0.05, **p < 0.01, ***p < 0.001 vs. respective vehicle group, ^## p < 0.01, ^### p < 0.001 vs. respective EMD 386088 group