Table 5.
Effect of EMD 386088, SCH 23390, and sulpiride given alone or in combination on the rat locomotor activity measured in the OF test
| Treatment | Dose (mg/kg) | Exploratory activity | |||
|---|---|---|---|---|---|
| Total distance (cm) | Rearings | Ambulation X | Ambulation Y | ||
| Vehicle + vehicle | 0 + 0 | 2477 ± 164 | 65 ± 9 | 224 ± 28 | 236 ± 22 |
| Vehicle + SCH 23390 | 0 + 0.063 | 1898 ± 196 | 55 ± 8 | 125 ± 13* | 136 ± 13* |
| Vehicle + EMD 386088 | 0 + 5 | 3354 ± 358 | 86 ± 10 | 308 ± 29 | 330 ± 28* |
| SCH 23390 + EMD 386088 | 0.063 + 5 | 2227 ± 190 | 62 ± 5 | 172 ± 25 | 188 ± 22 |
| F(1, 23) = 1.4296; NS | F(1, 23) = 0.6977; NS | F(1, 23) = 0.5631; NS | F(1, 23) = 0.9170; NS | ||
| Vehicle + vehicle | 0 + 0 | 2693 ± 222 | 84 ± 7 | 234 ± 26 | 237 ± 23 |
| Vehicle + sulpiride | 0 + 10 | 3324 ± 332 | 66 ± 9 | 352 ± 13 | 325 ± 35 |
| Vehicle + EMD 386088 | 0 + 5 | 3354 ± 358 | 86 ± 10 | 308 ± 29 | 330 ± 28 |
| Sulpiride + EMD 386088 | 5 + 10 | 3106 ± 358 | 81 ± 8 | 345 ± 32 | 357 ± 37 |
| F(1, 20) = 2.4700; NS | F(1, 20) = 0.5780; NS | F(1, 20) = 1.4950; NS | F(1, 20) = 0.9490; NS | ||
EMD 386088 was injected i.p. 30 min, while the remaining compounds were injected 60 min before. Values represent the mean ± SEM during the 5-min test session compared to the respective vehicle + vehicle group (two-way ANOVA is followed by the Duncan’s post hoc test) (N = 6)
NS not significant
*p < 0.05