Table 1.

Baseline contraction characteristics. Nerve-mediated contractions and potency of adenosine to reduce contractions in detrusor smooth muscle from human and guinea-pig bladders. NDO: neuropathic detrusor overactivity. Mean data ± SD; *p < 0.05, **p < 0.01 vs NDO human bladder. Values in parenthesis are the number of preparations

	Human stable bladder	Human NDO bladder	Guinea-pig bladder
T max, mN.mm−2	34.6 ± 21.1 (16)	44.3 ± 22.6 (18)	42.1 ± 13.8 (24)
f 1/2, Hz	13.7 ± 4.3 (16)	10.9 ± 2.1 (18) *	9.2 ± 3.9 (24) **
Atropine resistance, %	2.4 ± 1.9 (16)	37.4 ± 22.5 (17) **	53.8 ± 15.4 (9) **
T 4/40	0.102 ± 0.015 (16)	0.140 ± 0.015 (18) **	0.167 ± 0.062 (24) **
Adenosine pIC50	3.70 ± 0.52 (5) (IC50 = 199 μM)	3.65 ± 0.54 (5) (IC50 = 224 μM)	3.86 ± 0.33 (11) (IC50 = 138 μM)