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. Author manuscript; available in PMC: 2016 Jul 10.
Published in final edited form as: J Biol Rhythms. 2015 Jul 6;30(5):396–407. doi: 10.1177/0748730415593377

Figure 4.

Figure 4

Mice lacking Kv1.4 and Kv4.2 adjust to an advanced light cycle faster and are more active during the day and at night than wild-type (WT) mice. The Kv1.4−/−/Kv4.2−/− (n = 17) mice shifted their onsets of activity to match the light cycle faster than WT (n = 12) mice when the light cycle was advanced by 6 h (B) but not following a 6-h delay in the light cycle (A). The Kv1.4−/−/Kv4.2−/− mice also ran more (C) and ran for longer (D) in constant darkness. In a light cycle, the Kv1.4−/−/Kv4.2−/− mice were more active at all times, especially during the light phase (E and F). Data shown are means ± SEM. *p < 0.01, Student t test.