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. Author manuscript; available in PMC: 2016 Jul 10.
Published in final edited form as: J Cyst Fibros. 2011 Mar 26;10(4):243–252. doi: 10.1016/j.jcf.2011.03.001

Fig. 1.

Fig. 1

Potentiation effects of genistein and curcumin on whole-cell currents of G551D-CFTR channels expressed in CHO cells. (A) Effect of curcumin on G551D-CFTR whole-cell currents stimulated by 10 μM FSK+100 μM CPT-cAMP. Representative traces for G551D-CFTR whole-cell currents affected by 30 μM curcumin. The right panel shows the I–V relationships in control (at II) and curcumin (at III) after the subtraction of the leak-currents in the pulse at the position I. Representative of twelve data. (B) Effect of genistein on G551D-CFTR whole-cell currents stimulated by 10 μM FSK+100 μM CPT-cAMP. Representative traces for G551D-CFTR whole-cell currents affected by 80 μM genistein. The right panel shows the net I–V relationships in control (II–I) and genistein (III–I). Representative of eleven data. (C) The dose response relationship for genistein (●) (n=11) and curcumin (■) (n=12). Error bars represent SEM. The fold-increase in the whole cell current (IWC) was calculated by dividing the mean current at 100 mV in the presence of genistein or curcumin by the mean current in control after the leak current subtraction.