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. Author manuscript; available in PMC: 2016 Jul 10.
Published in final edited form as: J Cyst Fibros. 2011 Mar 26;10(4):243–252. doi: 10.1016/j.jcf.2011.03.001

Fig. 2.

Fig. 2

Potentiation effects of genistein and curcumin on G551D-CFTR observed in cell-attached mode. Representative cell-attached single-channel recordings of cAMP-stimulated G551D-CFTR channel currents potentiated by genistein (A) and curcumin (B). The G551D-CFTR channels are continuously stimulated by 10 μM FSK and 100 μM CPT-cAMP. Vp=+50 mV. Single channel amplitude: (A) control: 0.26 pA, genistein: 0.26 pA, wash out: 0.22 pA, (B) control: 0.41 pA, curcumin: 0.31 pA, wash out: 0.53 pA. (C) Summary of fold-increase of NPo induced by 80 μM genistein (n=5) and 30 μM curcumin (n=5). G551D-CFTR was expressed in CHO cells. Error bars represent SEM. Non-paired t-test, **: P<0.01.