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Pareto frontier for (top) 2-breakpoint, (middle) 6-breakpoint, and (bottom) 8-breakpoint beta-lactamase designs (x-axis: diversity; y-axis: perturbation). Green dots: Pareto optimal designs discovered by PEPFR; red crosses: designs (not necessarily Pareto optimal) sampled by the STAVERSITY method of Zheng et al. [67]
