Interleukin 6 (IL-6) was positively associated with performance on (A) Simple Movement Time (SMT), (B) Choice Movement Time, and (C) the Psychomotor Factor Score in linear regression analyses after controlling for sex, age, race, education, body mass index (BMI), and depression (as measured by the 17-item Hamilton Rating Scale for Depression (HAM-D) minus the psychomotor retardation item). (A) IL-6 concentration and time on the SMT were positively correlated (r = 0.25, p = 0.015). (B) IL-6 concentration and time on the CMT were positively correlated (r = 0.24, p = 0.026). (C) IL-6 concentration and the psychomotor factor score were positively correlated (r = 0.34, p = 0.001). All results are expressed as the natural log (Log) of the indicated variables, except for the Factor Score, which was calculated from the Log of the individual psychomotor tasks.