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Proposed steps in the PIK (A) and TMC (B) polyketide biosynthetic pathway. KS= ketosynthase, AT= acyltransferase, ACP= acyl carrier protein, DH= dehydratase, KR= ketoreductase, ER= enoylreductase, TE= thioesterase. Domains predicted to be inactive are crossed out. Domains that are active but not utilized are indicated with a star.
