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. 2016 May;5(1):14–19. doi: 10.15420/aer.2016.8.2

Figure 2: Key Ion Currents Shaping the Cardiac Action Potential.

Figure 2:

A: Schematic action potential, its phases and the ionic current contribution to the action potential. CSQ2 = calsequestrin 2; PLB = phospholamban; RyR2 = type-2 ryanodine receptor; SERCA2a = sarcoplasmic reticulum Ca2+ ATPase type-2a; INa = Na+ current; Ito = transient outward K+ current; ICa,L = L-type Ca2+ current; INCX = Na+-Ca2+ exchange current; IK,ATP = ATP-sensitive K+ current; IKr = rapid component of delayed-rectifier K+ current (IK); IKs = slow component of IK; IK1 = inward-rectifier K+ current. B: Representation of ion currents and Ca2+ handling proteins in ventricular cardiomyocytes.