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Factors associated with the formation of the three kinds of MNGCs detected around β-TCP granules implanted into rat subcutaneous tissue. Osteoclasts were induced in the region with osteogenesis after the implantation of BMMCs. In the presence of plasma, the expression of CTSK was stimulated and CTSK (+) MNGCs were frequently detected. Without plasma, CTSK (−) MNGCs, which had the typical characteristics of FBGCs, were detected.
