Table 4.
Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|
Hazard ratio for death (95% confidence interval) | p value | Hazard ratio for death (95% confidence interval) | p value | ||
Gender | Female | 1 ref. | 1 ref. | ||
Male | 1.659 (0.630–4.368) | 0.305 | 1.647 (0.524–5.180) | 0.393 | |
| |||||
Location of tumor | Rectum | 1 ref. | 1 ref. | ||
Colon | 1.418 (0.524–3.836) | 0.492 | 1.555 (0.480–5.031) | 0.461 | |
| |||||
Differentiation | Well | 1 ref. | 1 ref. | ||
Moderately | 0.700 (0.234–2.091) | 0.523 | 0.756 (0.221–2.587) | 0.656 | |
Poorly | 0.546 (0.147–2.031) | 0.367 | 0.375 (0.076–1.840) | 0.227 | |
| |||||
TNM stage | I | 1 ref. | 1 ref. | ||
II | 0.561 (0.103–3.065) | 0.505 | 0.621 (0.097–3.969) | 0.614 | |
III | 0.758 (0.379–8.142) | 0.471 | 3.848 (0.612–24.192) | 0.151 | |
IV | 4.277 (0.599–30.522) | 0.147 | 10.087 (0.803–126.629) | 0.073 | |
| |||||
Family history | No | 1 ref. | 1 ref. | ||
Yes | 0.672 (0.256–1.768) | 0.421 | 0.746 (0.210–2.655) | 0.651 | |
| |||||
Adjuvant therapy | No | 1 ref. | 1 ref. | ||
Yes | 1.224 (0.430–3.482) | 0.705 | 0.274 (0.063–1.195) | 0.085 | |
| |||||
MSI results | MSS | 1 ref. | 1 ref. | ||
MSI-L | 0.915 (0.251–3.336) | 0.893 | 2.105 (0.584–7.580) | 0.255 | |
MSH | 2.026 (0.635–6.462) | 0.233 | 0.512 (0.094–2.797) | 0.440 | |
| |||||
Metastases | No | 1 ref. | 1 ref. | ||
Yes | 0.392 (0.145–1.061) | 0.065 | 2.799 (0.707–11.084) | 0.143 | |
| |||||
Age of diagnosis | <50 | 1 ref. | 1 ref. | ||
>50 | 0.723 (0.274–1.907) | 0.512 | 2.240 (0.546–9.182) | 0.263 |