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The ERK pathway inhibitor PD98059 attenuated the protective effects of Artemisinin. D407 cells were pre-treated with 30 µM Artemisinin and 25 µM PD98059 for 2 h and then incubated with or without H2O2 for a further 24 h. Cell viability and caspase 3/7 activity were measured by MTT assay (A) and caspase 3/7 activity assay (B). ###P<0.005 versus control group;*P<0.05,**P<0.01 versus the Artemisinin+H2O2-treated group was considered significantly different.
