Table 4.
Adherence, IOP, and visual field progression throughout treatment, Primary Open-Angle African-American Glaucoma Genetics study, United States.
| Characteristic | Blind | Non-blinda | p-valueb |
|---|---|---|---|
| Subjects (eyes), n | 34 (40)a | 58 (58)a | |
| Length of follow-up, mean ± SD years | 9.51 ± 8.24 | 8.24 ± 5.97 | 0.43 |
| Visits/year, mean ± SD, n | 5.58 ± 3.20 | 3.97 ± 3.76 | 0.11 |
| Missed visits/year, mean ± SD, n | 2.32 ± 2.02 | 1.18 ± 0.75 | 0.003 |
| Visits missed, mean ± SD, n | 29.0 ± 14.9 | 24.9 ± 14.3 | 0.53 |
| Non-adherence to treatment noted in chart, mean ± SD, % | 19.3 ± 19.3 | 10.7 ± 13.2 | 0.03 |
| IOP maximum, mean ± SD, mmHg | 32.9 ± 10.7 | 22.6 ± 7.0 | <0.0001 |
| IOP minimum, mean ± SD, mmHg | 10.2 ± 5.2 | 10.8 ± 2.8 | 0.61 |
| Average IOP throughout treatment, mean ± SD, mmHg | 18.9 ± 4.9 | 15.5 ± 3.1 | 0.0001 |
| Visits with elevated IOP (≥21 mmHg), mean ± SD, % | 33.9 ± 28.3 | 10.9 ± 17.7 | <0.0001 |
| IOP standard deviation, mean ± SD, mmHg | 5.03 ± 2.60 | 2.77 ± 1.37 | <0.0001 |
| IOP relative standard deviation, mean ± SD, % | 27.6 ± 17.2 | 17.4 ± 6.4 | 0.001 |
| Mean decrease in IOP from pre- treatment, mean ± SD, mmHg | 8.99 ± 7.88 | 5.25 ± 3.98 | 0.002 |
| Eyes, n | 59 | 59 | |
| Number of visits with reliable visual field, n (%) | |||
| 1 | 11 (18.6) | 5 (8.5) | <0.0001 |
| 2 | 3 (5.1) | 6 (10.2) | |
| 3 | 25 (42.4) | 13 (22.0) | |
| 4 | 7 (11.9) | 35 (59.3) | |
| PSD progression rate, mean (SE), dB/year | 0.11 (0.06) | 0.01 (0.04) | 0.004 |
| Mean deviation progression rate, mean (SE), dB/year | −0.25 (0.19) | 0.05 (0.13) | <0.0001 |
Those who presented blind (16 blind eyes) and those who had <2 followup visits (3 blind eyes, 1 non-blind eye) were not included in this analysis as they were not able to contribute any meaningful data to these variables. Exceptions were length of follow-up and mean decrease in IOP from pre-treatment; for these two variables, data from those presenting blind were still excluded (16 blind eyes), but data from those with <2 follow-up visits were included.
Paired t-test for comparing means, McNemar’s test for comparing proportions for subject-level characteristics, and generalized estimating equations for eye-specific characteristics.
SD, standard deviation; SE, standard error; IOP, intraocular pressure; PSD, pattern standard deviation.