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. 2016 Jan 1;22(1):40–52. doi: 10.1089/mdr.2015.0079

Table 1.

The Guidelines Used to Determine the Antimicrobial Resistance Breakpoints Using the Disk-Diffusion and Broth Microdilution Methods

  Result for method
  Broth microdilution Disk diffusion
    MIC breakpoints (μg/ml)   Zone diameter breakpoint (mm)
Antimicrobial agent Test range (μg/ml) S I R Disk conc. (μg) S I R
Ampicillin 0.03–64.0 ≤8 16 ≥32 10 ≥17 14–16 ≤13
Ciprofloxacin 0.03–64.0 ≤1 2 ≥4 5 ≥21 16–20 ≤15
Erythromycin 0.03–64.0 ≤8 16 ≥32 15 ≥23 14–22 ≤13
Gentamicin 0.03–64.0 ≤2 4 ≥8 10 ≥15 13–14 ≤12
Streptomycin 0.03–64.0 ≤2 4 ≥8 10 ≥15 12–14 ≤11
Tetracycline 0.03–64.0 ≤4 8 ≥16 30 ≥15 12–14 ≤11
Tylosin 0.03–64.0 ≤4 8 ≥16 NT
Azithromycin NT 15 ≥18 14–17 ≤13
Chloramphenicol NT 30 ≥18 13–17 ≤12
Nalidixic acid NT 30 ≥19 14–18 ≤13

I, intermediate; MIC, minimum inhibitory concentrations; NT, not tested; R, resistance; S, susceptible.