Figure 7.

Domain-domain interaction sites highlighted by solid circles. The interaction regions found in structure ensembles E1, E2, E3, and E4 are indicated by labels E1, E2, E3, and E4, respectively. (a and d) Electrostatic potential surfaces of RRM1 and RRM2 calculated by using DELPHI. Electrostatic potential is colored from blue (positive charge) to red (negative charge). (b and e) Hydrophobic surfaces of RRM1 and RRM2. Hydrophobic residues (Phe, Trp, Tyr, Leu, Ile, Val, Met, Ala, Pro, and Gly) are colored in yellow, while hydrophilic residues (Thr, Ser, Lys, His, Glu, Gln, Asn, Asp, and Arg) are in gray. (c and f) Ribbon diagrams of RRM1 and RRM2 domains showing the orientation of each domain in the surface representations.