Table 3. Summary of the most differentially expressed genes upon growth of S. pneumoniae TIGR4 with Carolacton for 180 min.
| Locus tag | Gene product | Gene symbol | log2FCa | FDR |
|---|---|---|---|---|
| Galactose uptake (PTS)/N-acetylgalactosamine uptake (PTS)/Protein export | ||||
| sp_0324 | PTS system transporter subunit IIC | 4.68 | 7.52E-91 | |
| sp_0325 | PTS system transporter subunit IID | 4.56 | 5.10E-123 | |
| sp_0322 | glucuronyl hydrolase | 4.73 | 2.58E-100 | |
| sp_0327 | hypothetical protein | 4.41 | 5.05E-74 | |
| sp_0323 | PTS system transporter subunit IIB | 4.80 | 2.75E-95 | |
| sp_0326 | preprotein translocase subunit | yajC | 4.55 | 5.11E-74 |
| sp_0321 | PTS system transporter subunit IIA | 4.96 | 6.23E-89 | |
| Carbon metabolism/Pentose phosphate pathway | ||||
| sp_0318 | carbohydrate kinase | 4.13 | 1.30E-67 | |
| sp_0320 | gluconate 5-dehydrogenase | 4.08 | 1.82E-78 | |
| sp_0317 | 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase | 3.82 | 6.60E-64 | |
| sp_0319 | hypothetical protein | 3.88 | 4.69E-72 | |
| Protein degradation | ||||
| sp_0338 | ATP-dependent Clp protease, ATP-binding subunit | 3.73 | 4.09E-67 | |
| MutT/nudix family protein/transfer RNA biogenesis | ||||
| sp_0119 | MutT/nudix family protein | 4.44 | 2.57E-67 | |
| sp_0120 | tRNA uridine 5-carboxymethylaminomethyl modification protein | gidA | 4.33 | 1.35E-50 |
| Phosphate (Pi) uptake (ABC transporter) | ||||
| sp_2087 | phosphate transporter ATP-binding protein | pstB | 2.96 | 1.16E-45 |
| sp_2086 | phosphate ABC transporter permease | pstA | 2.97 | 1.34E-42 |
| sp_2084 | phosphate ABC transporter permease | pstS | 2.89 | 2.78E-38 |
| sp_2085 | phosphate ABC transporter substrate-binding protein | pstC | 2.96 | 2.78E-33 |
| sp_2088 | phosphate transport system regulatory protein | phoU | 3.19 | 5.26E-42 |
| sp_0789 | conserved hypothetical protein | 2.64 | 2.13E-37 | |
| sp_0790 | conserved hypothetical protein | 2.58 | 2.77E-44 | |
| sp_0018 | hypothetical protein | 2.10 | 1.13E-24 | |
| Genetic competence | ||||
| sp_2207 | competence protein | comFC | 2.21 | 2.18E-05 |
| sp_2208 | helicase | comFA | 2.22 | 3.04E-09 |
| sp_1793 | hypothetical protein | 2.17 | 9.19E-32 | |
| sp_1777 | hypothetical protein | 2.22 | 2.46E-25 | |
| sp_2013 | hypothetical protein | 2.13 | 4.64E-31 | |
| Nicotinate and nicotinamide metabolism | ||||
| sp_2015 | IS630-Spn1, transposase Orf1 | 2.74 | 2.48E-40 | |
| sp_2016 | nicotinate-nucleotide pyrophosphorylase | 2.60 | 1.07E-46 | |
| sp_0539 | bacteriocin | blpM | 2.59 | 1.38E-04 |
| Starch and sucrose metabolism | ||||
| sp_1722 | PTS system IIABC components | 0.87 | 6.04E-04 | |
| sp_1314 | IS66 family element, Orf1 | −3.11 | 7.89E-03 | |
| sp_1803 | hypothetical protein | −1.35 | 3.02E-09 | |
| Central carbon/lipid metabolism | ||||
| sp_0252 | fructose-6-phosphate aldolase | −2.34 | 4.59E-06 | |
| sp_0253 | glycerol dehydrogenase | −2.57 | 2.21E-07 | |
| sp_0251 | formate acetyltransferase | −2.29 | 8.60E-06 | |
| Cellobiose uptake (PTS) | ||||
| sp_0248 | PTS system transporter subunit IIA | −2.30 | 8.11E-05 | |
| sp_0250 | PTS system transporter subunit IIC | −2.28 | 1.85E-05 | |
| sp_0249 | PTS system transporter subunit IIB | −2.42 | 4.79E-05 | |
Horizontal lines indicate separation of transcriptional units.
acut-off: log2FC≥2 or ≤−2 at one point during the time course.