Figure 6. APAP-induced liver injury following the adoptive transfer of neutrophils from WT or BLT₁^−/− mice.

Murine neutrophils were isolated from the BM of WT or BLT₁^−/− mice. BM neutrophils of each genotype were injected intravenously into WT or BLT₁^−/− mice at 6 h after APAP treatment. The ALT level (A), hepatic necrotic area (B) and number of hepatic Gr-1-positive cells (C) in WT mice that received WT neutrophils (WT Neut → WT) or BLT₁^−/− neutrophils (BLT₁^−/− Neut → WT) were determined at 24 h after APAP administration. Data are expressed as the means ± SEM of five mice per group. *p < 0.05 vs. WT Neut → WT mice. Neut, neutrophils.