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. Author manuscript; available in PMC: 2016 Jul 11.
Published in final edited form as: Curr Top Dev Biol. 2016 Jan 7;117:75–91. doi: 10.1016/bs.ctdb.2015.11.027

Figure 1.

Figure 1

Domain organization of Dishevelled (Dsh) proteins and pathway-specific requirements and interactions. Dsh (in Drosophila 623 aa long) is shown in blue with its three main and highly conserved domains, DIX, PDZ, and DEP, labeled accordingly. The color scheme is “red” for canonical Wnt/β-catenin signaling and “black” for Wnt–Fz/PCP signaling. The three domains have their “main” pathway-specific interactors shown in the respective color and the red and black bars below Dsh indicate the approximate extent of requirements for signal relay to the respective pathways. Frizzled receptors directly interact with the PDZ domain and as this interaction is needed for both signaling outcomes it kept in blue. See text for details.