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. Author manuscript; available in PMC: 2016 Oct 20.
Published in final edited form as: Anal Chem. 2015 Oct 1;87(20):10627–10634. doi: 10.1021/acs.analchem.5b03180

Figure 1.

Figure 1

Covalent labeling results for β2m. Spheres represent residues that were labeled with DEPC. The color indicates whether the residue has undergone any significant change in labeling after being exposed to a perturbing condition (blue: decrease, red: increase, gray: no change). A) Heating at 75°C for 24 hours. B) Oxidation with 3% H2O2 for 24 hours. Changes in covalent labeling are mapped onto the NMR structure of β2m (PDB accession code: 2XKS).