Table 2.
Number of residues within each domain of IgG1 whose relative labeling change after heating is statistically significant and whose value falls within the labeled bin.
| Domaina | < −80% | < −40% | < −10% | Total De- crease |
> 200% |
> 100% |
> 10% | Total In- crease |
|---|---|---|---|---|---|---|---|---|
| VL | 12 | 8 | 1 | 21 | 4 | 0 | 0 | 4 |
| CL | 10 | 3 | 3 | 16 | 12 | 3 | 2 | 17 |
| VH | 13 | 2 | 1 | 16 | 13 | 1 | 1 | 15 |
| CH1 | 9 | 2 | 1 | 12 | 13 | 4 | 2 | 19 |
| CH2 | 9 | 5 | 0 | 14 | 4 | 3 | 3 | 10 |
| CH3 | 5 | 6 | 0 | 11 | 4 | 1 | 3 | 8 |
a
CL and VL represent the constant and variable domains of the light chain. VH and CH1–3 represent the variable and the three constant domains of the heavy chain, respectively.