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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Neurobiol Aging. 2016 Apr 27;44:53–61. doi: 10.1016/j.neurobiolaging.2016.04.011

Fig 2.

Fig 2

Change in translocator protein 18 kDa (TSPO) binding increases with worsening clinical severity in patients with either mild cognitive impairment (MCI) or Alzheimer’s disease (AD) at baseline. (A) Interval change in 11C-PBR28 binding correlated with change in Clinical Dementia Rating scale – sum of boxes (CDR-SB). Values are corrected for age at baseline and education. R = 0.717, P = 0.004. (B) Surface-based maps showing areas where change in 11C-PBR28 binding correlated with change in CDR-SB scores, corrected for patient age at baseline and education level. Color bars denote P-values in logarithmic scale (e.g., 1.3 = P-value of 0.05, 3 = P-value of 0.001).