FIG. 7.

Schematic showing the effect of gestational T excess on insulin sensitivity in the liver, muscle, and adipose tissue in fetuses and adult female sheep. Gestational T treatment promotes tissue-specific changes that indicate increased insulin sensitivity in the liver, decreased insulin sensitivity in the muscle, and unaltered insulin sensitivity in the adipose tissue in GD90 fetuses. In adult sheep, prenatal T excess induces tissue-specific changes that point to reduced insulin sensitivity in both the liver and muscle; ↓: reduced expression; ↑: increased expression; (–): unaltered expression.