FIG. 7.

Model of disease phenotype of eMSC and eSF in endometriosis. Top panel: normal eMSC progenitors differentiate both in vivo and in vitro to eSF that decidualize in response to P₄. Bottom panel: in endometriosis, in vivo differentiated eSF inherit P₄ resistance from eMSC progenitors failing to decidualize, and also acquire a pro-inflammatory phenotype within the endometrial niche. The eMSC from endometriosis differentiate in vitro to eSF that inherit P₄ resistance with impaired decidualization, but eMSC differentiated to eSF outside of the endometrial niche do not acquire the pro-inflammatory phenotype displayed by their in vivo differentiated counterparts.