Table 2.

Recommended salvage therapy regimens for Helicobacter pylori eradication

Treatment	Drugs, dosages and duration
Empiric salvage therapy	(After 2 or more failures with different drugs)
Furazolidone quadruple therapy with tetracycline	Bismuth subsalicylate or bismuth subcitrate 2 tablets and tetracycline hydrochloride (500 mg) both four times daily with meals and at bedtime plus furazolidone 100 mg t.i.d., with meals and PPI twice daily for 14 days
Furazolidone quadruple therapy with amoxicillin	Bismuth subsalicylate or bismuth subcitrate 2 four times daily with meals and at bedtime plus furazolidone 100 mg and amoxicillin 1 gram t.i.d., with meals plus a PPI twice daily for 14 days
Rifabutin therapies	See Table 3.
High dose PPI-amoxicillin dual therapy	PPI (e.g. rabeprazole 20 mg, esomeprazole 40 mg) plus amoxicillin (500 - 750 mg) all four times daily at approximately 6 h intervals for 14 days (can use 8 hour interval at night) (effective for CYP2C19 poor metabolizers - see text)

Preferred PPI's: Esomeprazole 40 mg, rabeprazole 20 mg.