Table 2.
Treatment | Drugs, dosages and duration |
---|---|
Empiric salvage therapy | (After 2 or more failures with different drugs) |
Furazolidone quadruple therapy with tetracycline |
Bismuth subsalicylate or bismuth subcitrate 2 tablets and tetracycline hydrochloride (500 mg) both four times daily with meals and at bedtime plus furazolidone 100 mg t.i.d., with meals and PPI twice daily for 14 days |
Furazolidone quadruple therapy with amoxicillin |
Bismuth subsalicylate or bismuth subcitrate 2 four times daily with meals and at bedtime plus furazolidone 100 mg and amoxicillin 1 gram t.i.d., with meals plus a PPI twice daily for 14 days |
Rifabutin therapies | See Table 3. |
High dose PPI-amoxicillin dual therapy |
PPI (e.g. rabeprazole 20 mg, esomeprazole 40 mg) plus amoxicillin (500 - 750 mg) all four times daily at approximately 6 h intervals for 14 days (can use 8 hour interval at night) (effective for CYP2C19 poor metabolizers - see text) |
Preferred PPI's: Esomeprazole 40 mg, rabeprazole 20 mg.