Table 4.

Multivariable regression analysis of associations between ≥95% compliance with central line bundle elements and CLABSI rates in adult ICUs

Variables	Model 1: Impact of each individual element		Model 2: Impact of complying with any one or multiple elements
	IRR	95% CI	IRR	95% CI
≥95% compliance with
Hand hygiene	0.91	0.80, 1.05	--	--
Maximal barrier precautions	0.96	0.83, 1.11	--	--
Chlorhexidine use	0.89	0.78, 1.02	--	--
Optimal catheter site selection	0.90	0.80, 1.00	--	--
Daily assessment of central line need	0.99	0.89, 1.10	--	--
CLABSI bundle elements (indicator variables with reference = no elements)
All five elements	--	--	0.67***	0.59, 0.77
Just four elements	--	--	0.72***	0.63, 0.82
Just three elements	--	--	0.83**	0.74, 0.94
Just two elements	--	--	0.82*	0.70, 0.95
Just one element	--	--	0.77**	0.64, 0.92
Compliance with ventilator bundle	1.06***	1.03, 1.08	1.06***	1.03, 1.08
Compliance with CAUTI bundle	1.00	0.94, 1.06	1.00	0.94, 1.06
Hospital and ICU characteristics
Number of hospital beds	1.08**	1.03, 1.13	1.08***	1.03, 1.13
Number of ICU beds	0.94**	0.91, 0.98	0.95**	0.91, 0.98
Surgical ICU (vs. Medical/Surgical)	0.86**	0.78, 0.95	0.86**	0.78, 0.95
Medical ICU (vs. Medical/Surgical)	1.08	0.98, 1.20	1.09	0.99, 1.20
Burn or Trauma ICU (vs. Medical/Surgical)	1.64***	1.42, 1.90	1.62***	1.40, 1.87
Affiliated with a medical school	1.32***	1.19, 1.45	1.29***	1.17, 1.43
Electronic surveillance system	0.91*	0.83, 0.99	0.90*	0.83, 0.98
IP full-time equivalents per 100 hospital beds	0.87*	0.78, 0.97	0.88*	0.79, 0.98
HE full-time equivalents per 100 hospital beds	1.00	0.87, 1.16	0.99	0.86, 1.15

Notes: CLABSI = central line-associated bloodstream infection; ICU = intensive care unit; CAUTI = catheter-associated urinary tract infection; IRR = incidence rate ratio; CI = confidence interval; In addition to what is shown in the table, calendar year and month were also controlled for;

^*p<0.05,

^**p<0.01,

^***p<0.001